D-PLEX₅₀₀

PolyPid is developing D-PLEX₅₀₀* with its collaborator, MIS Implants Technologies Ltd., a subsidiary of Dentsply Sirona Inc., for use in periodontal and oral/maxillofacial surgeries to treat peri-implantitis, a destructive inflammatory process affecting the soft and hard tissues surrounding dental implants.

D-PLEX₅₀₀ is a member of our PLEX-doxycycline family that incorporates a synthetic bone graft substitute comprised of resorbable β-TCP granules.

D-PLEX₅₀₀  is designed to fill and reconstruct bone defects caused by peri-implantitis.

We have observed that D-PLEX₅₀₀ gradually reabsorbs and is replaced with bone during the healing process.

Upon hydration in the body, the PLEX™ matrix gradually degrades and allows the antibiotic entrapped in the layers to be released constantly into its surroundings while the bone filler acts as a scaffold to support osteoconductive bone recovery.

The antibacterial activity of the released antibiotic takes place in conjunction to the osteoconductive activity of the bone substitute, and prevents its potential rejection or early absorption by bacteria-related local bone infection and protects the surface of the graft from the development of biofilm.

D-PLEX₅₀₀ is not yet approved for sale by regulatory agencies.

*Formally known as BonyPid^®-500