Resources

A rationally designed local delivery platform (OncoPLEX) for sustained docetaxel release to overcome therapeutic barriers in post-resection solid tumors and glioblastoma

Evaluation of ASEPSIS Score as a Secondary Endpoint in the Phase 3 SHIELD II Trial of DPLEX₁₀₀ in Colorectal Surgery

SIS 2026 Abstract Submission_20NOV2025 FINAL

Pharmacokinetics of Local Extended-Release Incisional Doxycycline in Patients Undergoing Abdominal Colorectal Surgery from the SHIELD II Phase 3 Clinical Trial

ESCMID 2026 Abstract 

ESCMID 2026 poster – FINAL 

Efficacy of a Novel Local Prolonged-Release Incisional Doxycycline on Surgical Site Infection Prophylaxis in Abdominal Colorectal Surgery: The SHIELD II Phase 3 Randomized Clinical Trial

Effect of local prolonged-release incisional doxycycline on surgical site infection prophylaxis in abdominal colorectal surgery: the SHIELD 1 randomized clinical trial

Impact of Locally Applied Doxycycline-Eluting Drug (D-PLEX) on Incisional Infection Rate in Elective Colorectal Surgery: A Phase 3, Prospective, Randomized, Double-Blind, Multicenter and Multinational Clinical Trial

Preclinical In-Vivo Safety and Toxicokinetics of D-PLEX100 in an Abdominal Surgery Incision Model in Juvenile Miniature Swine

Potent antibacterial activity in surgical wounds with local administration of D-PLEX100

Reduction in surgical site infections by localized administration with D-PLEX100 in patients with multiple risk factors undergoing colorectal surgery

D-PLEX, a doxycycline releasing antimicrobial product for surgical site wounds, reduces surgical site infection rates and drug resistant-bacteria in surgical trauma injuries